Go up the stairwell and into the “Observation Room.” Go left down the stairs, over the glass-roofed patient rooms and watch a truly disturbed Nolan Stross on the monitor. Turn right to see two security guards succumb to the Necromorphs. Move forward and you will find a SAVE STATION. Go through the door and pump the action button to fend off the clutching Necromorph, which, if you’re successful, is crushed in the closing doorway. Pass through the two open doorways and turn left, sprinting ahead through the open doorway, bearing right and right again toward the large door ahead. You can run past the rampaging Necromorphs if you just keep sprinting. Pass through the left opening and then bear right after the first large support column in the broad hallway. When you gain control of Isaac, sprint down the left hallway without pausing. An Infector then attacks Franco and Isaac, still in the straightjacket, must immediately flee for his A frightened orderly named Franco has located him for someone named Daina, and tells him he is in grave danger.

After a cut scene recalling past events and horrors connected with the ill-fated events aboard the Ishimura, a dazed Isaac Clarke awakens, confined in a straightjacket.

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